2XWT

CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH A BLOCKING TYPE TSHR AUTOANTIBODY

Summary for 2XWT

Entry DOI	10.2210/pdb2xwt/pdb
Related	1XUM 3G04
Descriptor	THYROID BLOCKING HUMAN AUTOANTIBODY K1-70 HEAVY CHAIN, THYROID BLOCKING HUMAN AUTOANTIBODY K1-70 LIGHT CHAIN, THYROTROPIN RECEPTOR, ... (7 entities in total)
Functional Keywords	signaling protein-immune system complex, gpcr, graves' disease, autoimmunity, receptor-autoantibody complex, signaling protein/immune system
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	3
Total formula weight	74794.95
Authors	Sanders, J.,Sanders, P.,Young, S.,Kabelis, K.,Baker, S.,Sullivan, A.,Evans, M.,Clark, J.,Wilmot, J.,Hu, X.,Roberts, E.,Powell, M.,Nunez Miguel, R.,Furmaniak, J.,Rees Smith, B. (deposition date: 2010-11-05, release date: 2011-03-09, Last modification date: 2023-12-20)
Primary citation	Sanders, P.,Young, S.,Sanders, J.,Kabelis, K.,Baker, S.,Sullivan, A.,Evans, M.,Clark, J.,Wilmot, J.,Hu, X.,Roberts, E.,Powell, M.,Nunez Miguel, R.,Furmaniak, J.,Rees Smith, B. Crystal Structure of the Tsh Receptor (Tshr) Bound to a Blocking-Type Tshr Autoantibody. J.Mol.Endocrinol., 46:81-, 2011 Cited by PubMed: 21247981 DOI: 10.1530/JME-10-0127 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation