2XDW

Inhibition of Prolyl Oligopeptidase with a Synthetic Unnatural Dipeptide

Summary for 2XDW

Entry DOI	10.2210/pdb2xdw/pdb
Related	1E5T 1E8M 1E8N 1H2W 1H2X 1H2Y 1H2Z 1O6F 1O6G 1QFM 1QFS 1UOO 1UOP 1UOQ 1VZ2 1VZ3
Related PRD ID	PRD_000694
Descriptor	Prolyl endopeptidase, SYNTHETIC PEPTIDE PHQ-PRO-YCP, TRIS(HYDROXYETHYL)AMINOMETHANE, ... (5 entities in total)
Functional Keywords	alpha/beta-hydrolase, amnesia, beta-propeller, hydrolase, inhibitor
Biological source	Sus scrofa (pig) More
Cellular location	Cytoplasm: P23687
Total number of polymer chains	2
Total formula weight	82235.26
Authors	Racys, D.T.,Rea, D.,Fulop, V.,Wills, M. (deposition date: 2010-05-09, release date: 2010-06-23, Last modification date: 2024-11-06)
Primary citation	Racys, D.T.,Rea, D.,Fulop, V.,Wills, M. Inhibition of Prolyl Oligopeptidase with a Synthetic Unnatural Dipeptide Bioorg.Med.Chem., 18:4775-, 2010 Cited by PubMed Abstract: A new inhibitor, containing a linked proline-piperidine structure, for the enzyme prolyl oligopeptidase (POP) has been synthesised and demonstrated to bind covalently with the enzyme at the active site. This provides evidence that covalent inhibitors of POP do not have to be limited to structures containing five-membered N-containing heterocyclic rings. PubMed: 20627594 DOI: 10.1016/J.BMC.2010.05.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation