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2X9E

HUMAN MPS1 IN COMPLEX WITH NMS-P715

Summary for 2X9E
Entry DOI10.2210/pdb2x9e/pdb
Related2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP
DescriptorDUAL SPECIFICITY PROTEIN KINASE TTK, N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE (3 entities in total)
Functional Keywordskinase, serine/threonine-protein kinase, transferase, tyrosine-protein kinase, mitotic checkpoint
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight36916.38
Authors
Primary citationColombo, R.,Caldarelli, M.,Mennecozzi, M.,Giorgini, M.L.,Sola, F.,Cappella, P.,Perrera, C.,Depaolini, S.R.,Rusconi, L.,Cucchi, U.,Avanzi, N.,Bertrand, J.A.,Bossi, R.T.,Pesenti, E.,Galvani, A.,Isacchi, A.,Colotta, F.,Donati, D.,Moll, J.
Targeting the Mitotic Checkpoint for Cancer Therapy with Nms-P715, an Inhibitor of Mps1 Kinase.
Cancer Res., 70:10255-, 2010
Cited by
PubMed: 21159646
DOI: 10.1158/0008-5472.CAN-10-2101
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.1 Å)
Structure validation

217157

数据于2024-03-13公开中

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