2X9E
HUMAN MPS1 IN COMPLEX WITH NMS-P715
Summary for 2X9E
Entry DOI | 10.2210/pdb2x9e/pdb |
Related | 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP |
Descriptor | DUAL SPECIFICITY PROTEIN KINASE TTK, N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE (3 entities in total) |
Functional Keywords | kinase, serine/threonine-protein kinase, transferase, tyrosine-protein kinase, mitotic checkpoint |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 36916.38 |
Authors | Colombo, R.,Caldarelli, M.,Mennecozzi, M.,Giorgini, M.L.,Sola, F.,Cappella, P.,Perrera, C.,DePaolini, S.R.,Rusconi, L.,Cucchi, U.,Avanzi, N.,Bertrand, J.A.,Bossi, R.T.,Pesenti, E.,Galvani, A.,Isacchi, A.,Colotta, F.,Donati, D.,Moll, J. (deposition date: 2010-03-17, release date: 2010-12-29, Last modification date: 2023-12-20) |
Primary citation | Colombo, R.,Caldarelli, M.,Mennecozzi, M.,Giorgini, M.L.,Sola, F.,Cappella, P.,Perrera, C.,Depaolini, S.R.,Rusconi, L.,Cucchi, U.,Avanzi, N.,Bertrand, J.A.,Bossi, R.T.,Pesenti, E.,Galvani, A.,Isacchi, A.,Colotta, F.,Donati, D.,Moll, J. Targeting the Mitotic Checkpoint for Cancer Therapy with Nms-P715, an Inhibitor of Mps1 Kinase. Cancer Res., 70:10255-, 2010 Cited by PubMed: 21159646DOI: 10.1158/0008-5472.CAN-10-2101 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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