2ZMD

Crystal structure of human Mps1 catalytic domain T686A mutant in complex with SP600125 inhibitor

Summary for 2ZMD

Entry DOI	10.2210/pdb2zmd/pdb
Related	2ZMC
Descriptor	Dual specificity protein kinase TTK, 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, ... (4 entities in total)
Functional Keywords	kinase, mps1, sp600125, t686a, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	44848.97
Authors	Chu, M.L.H.,Chavas, L.M.G.,Douglas, K.T.,Eyers, P.A.,Tabernero, L. (deposition date: 2008-04-16, release date: 2008-05-13, Last modification date: 2023-11-01)
Primary citation	Chu, M.L.,Chavas, L.M.,Douglas, K.T.,Eyers, P.A.,Tabernero, L. Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125. J.Biol.Chem., 283:21495-21500, 2008 Cited by PubMed: 18480048 DOI: 10.1074/jbc.M803026200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.88 Å)

Structure validation