2X6V
Crystal structure of human TBX5 in the DNA-bound and DNA-free form
Summary for 2X6V
Entry DOI | 10.2210/pdb2x6v/pdb |
Related | 2X6U |
Descriptor | T-BOX TRANSCRIPTION FACTOR TBX5, 5'-D(*TP*CP*TP*CP*AP*CP*AP*CP*CP*TP*TP)-3', 5'-D(*TP*AP*AP*GP*GP*TP*GP*TP*GP*AP*GP)-3', ... (6 entities in total) |
Functional Keywords | transcription-dna complex, holt-oram-syndrome, developmental protein, transcription regulation, repressor, dna-binding, transcription, nuclear protein, transcription/dna |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus (Potential): Q99593 |
Total number of polymer chains | 4 |
Total formula weight | 53912.64 |
Authors | Ptchelkine, D.,Stirnimann, C.U.,Grimm, C.,Mueller, C.W. (deposition date: 2010-02-22, release date: 2010-04-28, Last modification date: 2023-12-20) |
Primary citation | Stirnimann, C.U.,Ptchelkine, D.,Grimm, C.,Muller, C.W. Structural Basis of Tbx5-DNA Recognition: The T-Box Domain in its DNA-Bound and -Unbound Form. J.Mol.Biol., 400:71-, 2010 Cited by PubMed: 20450920DOI: 10.1016/J.JMB.2010.04.052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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