2X6V
Crystal structure of human TBX5 in the DNA-bound and DNA-free form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 1239 |
| Chain | Residue |
| A | GLU60 |
| A | SER86 |
| A | LYS88 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG B 1233 |
| Chain | Residue |
| B | GLU60 |
| B | SER86 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PE4 B 1234 |
| Chain | Residue |
| B | PHE201 |
| A | LEU103 |
| A | ASP105 |
| A | ARG182 |
| B | ARG182 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 360 |
| Details | DNA_BIND: T-box => ECO:0000255|PROSITE-ProRule:PRU00201, ECO:0000269|PubMed:26926761 |
| Chain | Residue | Details |
| A | LEU58-GLY238 | |
| B | LEU58-GLY238 |
