2X5O

Discovery of Novel 5-Benzylidenerhodanine- and 5-Benzylidene- thiazolidine-2,4-dione Inhibitors of MurD Ligase

Summary for 2X5O

Entry DOI	10.2210/pdb2x5o/pdb
Related	1E0D 1EEH 1UAG 2JFF 2JFG 2JFH 2UAG 2UUO 2UUP 2VTD 2VTE 2WJP 3UAG 4UAG
Descriptor	UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE, N-({3-[({4-[(Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]PHENYL}AMINO)METHYL]PHENYL}CARBONYL)-D-GLUTAMIC ACID, AZIDE ION, ... (7 entities in total)
Functional Keywords	atp-binding, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, ligase, peptidoglycan synthesis
Biological source	Escherichia coli DH5[alpha]
Cellular location	Cytoplasm: P14900
Total number of polymer chains	1
Total formula weight	48096.99
Authors	Zidar, N.,Tomasic, T.,Sink, R.,Rupnik, V.,Kovac, A.,Turk, S.,Contreras-Martel, C.,Dessen, A.,Blanot, D.,Gobec, S.,Zega, A.,Peterlin-Masic, L.,Kikelja, D. (deposition date: 2010-02-10, release date: 2010-09-15, Last modification date: 2023-12-20)
Primary citation	Zidar, N.,Tomasic, T.,Sink, R.,Rupnik, V.,Kovac, A.,Turk, S.,Patin, D.,Blanot, D.,Contreras Martel, C.,Dessen, A.,Muller Premru, M.,Zega, A.,Gobec, S.,Peterlin Masic, L.,Kikelj, D. Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2,4-dione inhibitors of MurD ligase. J. Med. Chem., 53:6584-6594, 2010 Cited by PubMed: 20804196 DOI: 10.1021/jm100285g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.46 Å)

Structure validation