2X44

Structure of a strand-swapped dimeric form of CTLA-4

Summary for 2X44

Entry DOI	10.2210/pdb2x44/pdb
Related	1AH1 1H6E 1I85 1I8L
Descriptor	CYTOTOXIC T-LYMPHOCYTE PROTEIN 4 (2 entities in total)
Functional Keywords	immune system, amyloidogenic, systemic lupus erythematosus, immunoglobulin domain, membrane, glycoprotein, transmembrane
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	14092.07
Authors	Sonnen, A.F.-P.,Yu, C.,Evans, E.J.,Stuart, D.I.,Davis, S.J.,Gilbert, R.J.C. (deposition date: 2010-01-28, release date: 2010-04-07, Last modification date: 2024-11-20)
Primary citation	Sonnen, A.F.,Yu, C.,Evans, E.J.,Stuart, D.I.,Davis, S.J.,Gilbert, R.J.C. Domain Metastability: A Molecular Basis for Immunoglobulin Deposition? J.Mol.Biol., 399:207-, 2010 Cited by PubMed Abstract: We present the crystal structure of an immunoglobulin light-chain-like domain, CTLA-4, as a strand-swapped dimer displaying cis-trans proline isomerisation and native-like hydrogen bonding. We also show that CTLA-4 can form amyloid-like fibres and amorphous deposits explainable by the same strand swapping. Our results suggest a molecular basis for the pathological aggregation of immunoglobulin domains and why amyloid-like fibres are more often composed of homologous rather than heterologous subunits. PubMed: 20394753 DOI: 10.1016/J.JMB.2010.04.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation