1AH1

CTLA-4, NMR, 20 STRUCTURES

Summary for 1AH1

• Entry DOI: 10.2210/pdb1ah1/pdb
• Descriptor: CTLA-4, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: immunoreceptor, t cell receptor, immune response, immunoglobulin
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein: P16410
• Total number of polymer chains: 1
• Total formula weight: 15330.06

Authors

Metzler, W.J.,Bajorath, J.,Fenderson, W.,Shaw, S.-Y.,Peach, R.,Constantine, K.L.,Naemura, J.,Leytze, G.,Lavoie, T.B.,Mueller, L.,Linsley, P.S. (deposition date: 1997-04-11, release date: 1998-04-15, Last modification date: 2024-11-20)

Primary citation

Metzler, W.J.,Bajorath, J.,Fenderson, W.,Shaw, S.Y.,Constantine, K.L.,Naemura, J.,Leytze, G.,Peach, R.J.,Lavoie, T.B.,Mueller, L.,Linsley, P.S.
Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28.
Nat.Struct.Biol., 4:527-531, 1997

PubMed Abstract: The structure of human CTLA-4 reveals that residues Met 99, Tyr 100 and Tyr 104 of the M99YPPPY104 motif are adjacent to a patch of charged surface residues on the A'GFCC' face of the protein. Mutation of these residues, which are conserved in the CTLA-4/CD28 family, significantly reduces binding to CD80 and/or CD86, implicating this patch as a ligand binding site.

PubMed: 9228944
DOI: 10.1038/nsb0797-527

Experimental method

SOLUTION NMR