2X2M

Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor

2X2M の概要

• エントリーDOI: 10.2210/pdb2x2m/pdb
• 関連するPDBエントリー: 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L
• 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET, FORMIC ACID, (3Z)-3-[(3,5-DIMETHYL-1H-PYRROL-2-YL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE, ... (4 entities in total)
• 機能のキーワード: hirschsprung disease, gdnf receptor, transmembrane, proto-oncogene, phosphoprotein, disease mutation, phosphotransferase, ret, kinase, membrane, transferase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72283.12

構造登録者

Knowles, P.P.,Murray-Rust, J.,Kjaer, S.,McDonald, N.Q. (登録日: 2010-01-13, 公開日: 2010-02-09, 最終更新日: 2023-12-20)

• 主引用文献: Mologni, L.,Rostagno, R.,Brussolo, S.,Knowles, P.P.,Kjaer, S.,Murray-Rust, J.,Rosso, E.,Zambon, A.,Scapozza, L.,McDonald, N.Q.,Lucchini, V.,Gambacorti-Passerini, C.; Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.; Bioorg. Med. Chem., 18:1482-1496, 2010; PubMed: 20117004; DOI: 10.1016/j.bmc.2010.01.011

実験手法

X-RAY DIFFRACTION (2.5 Å)