2X1W

Crystal Structure of VEGF-C in Complex with Domains 2 and 3 of VEGFR2

2X1W の概要

• エントリーDOI: 10.2210/pdb2x1w/pdb
• 関連するPDBエントリー: 1VR2 1Y6A 1Y6B 1YWN 2X1X
• 分子名称: VASCULAR ENDOTHELIAL GROWTH FACTOR C, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: hormone-signaling protein complex, angiogenesis, glycoprotein, host-virus interaction, membrane, receptor, lymphangiogenesis, immunoglobulin domain, developmental protein, transmembrane, phosphoprotein, disulfide bond, mitogen, hormone/signaling protein
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 153988.60

構造登録者

Leppanen, V.M.,Prota, A.E.,Jeltsch, M.,Anisimov, A.,Kalkkinen, N.,Strandin, T.,Lankinen, H.,Goldman, A.,Ballmer-Hofer, K.,Alitalo, K. (登録日: 2010-01-08, 公開日: 2010-03-09, 最終更新日: 2020-07-29)

• 主引用文献: Leppanen, V.M.,Prota, A.E.,Jeltsch, M.,Anisimov, A.,Kalkkinen, N.,Strandin, T.,Lankinen, H.,Goldman, A.,Ballmer-Hofer, K.,Alitalo, K.; Structural Determinants of Growth Factor Binding and Specificity by Vegf Receptor 2.; Proc.Natl.Acad.Sci.USA, 107:2425-, 2010; PubMed: 20145116; DOI: 10.1073/PNAS.0914318107

実験手法

X-RAY DIFFRACTION (2.7 Å)