2X0L

Crystal structure of a neuro-specific splicing variant of human histone lysine demethylase LSD1.

2X0L の概要

• エントリーDOI: 10.2210/pdb2x0l/pdb
• 関連するPDBエントリー: 2COM 2H94 2IW5 2UXN 2UXX 2V1D
• 分子名称: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, HISTONE H3 PEPTIDE, ... (4 entities in total)
• 機能のキーワード: repressor complex, chromatin remodelling, amine oxidase, transcription, host-virus interaction, transcription regulation, phosphoprotein, oxidoreductase, nuclear protein, chromatin regulator, developmental protein
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Nucleus : O60341 Q9UKL0; Chromosome . Nucleus : Q5TEC6
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 99491.86

構造登録者

Zibetti, C.,Adamo, A.,Binda, C.,Forneris, F.,Verpelli, C.,Ginelli, E.,Mattevi, A.,Sala, C.,Battaglioli, E. (登録日: 2009-12-15, 公開日: 2010-03-02, 最終更新日: 2023-12-20)

• 主引用文献: Zibetti, C.,Adamo, A.,Binda, C.,Forneris, F.,Toffolo, E.,Verpelli, C.,Ginelli, E.,Mattevi, A.,Sala, C.,Battaglioli, E.; Alternative Splicing of the Histone Demethylase Lsd1/Kdm1 Contributes to the Modulation of Neurite Morphogenesis in the Mammalian Nervous System.; J.Neurosci., 30:2521-, 2010; PubMed: 20164337; DOI: 10.1523/JNEUROSCI.5500-09.2010

実験手法

X-RAY DIFFRACTION (3 Å)