2WJ1

3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(4-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole

2WJ1 の概要

• エントリーDOI: 10.2210/pdb2wj1/pdb
• 関連するPDBエントリー: 1MT5 2VYA 2WAP
• 分子名称: FATTY-ACID AMIDE HYDROLASE 1, 7-phenyl-1-(4-pyridin-2-yl-1,3-oxazol-2-yl)heptane-1,1-diol, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: monotopic membrane protein, fatty acid amide hydrolase, golgi apparatus, endoplasmic reticulum, membrane, hydrolase, transmembrane, phosphoprotein, covalent reversible inhibitor
• 由来する生物種: RATTUS NORVEGICUS (RAT)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 126963.63

構造登録者

Mileni, M.,Garfunkle, J.,DeMartino, J.K.,Cravatt, B.F.,Boger, D.L.,Stevens, R.C. (登録日: 2009-05-19, 公開日: 2009-09-15, 最終更新日: 2023-12-13)

• 主引用文献: Mileni, M.,Garfunkle, J.,Demartino, J.K.,Cravatt, B.F.,Boger, D.L.,Stevens, R.C.; Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by Alpha-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures.; J.Am.Chem.Soc., 131:10497-, 2009; PubMed: 19722626; DOI: 10.1021/JA902694N

実験手法

X-RAY DIFFRACTION (1.84 Å)