2WCX

Crystal Structure of Hepatitis C Virus NS5B Polymerase in Complex with Thienopyrrole-Based Finger-Loop Inhibitors

2WCX の概要

• エントリーDOI: 10.2210/pdb2wcx/pdb
• 関連するPDBエントリー: 1A1Q 1C2P 1CSJ 1CU1 1GX5 1GX6 1JXP 1NHU 1NHV 1NS3 1OS5 1QUV 2AWZ 2AX0 2AX1 2BRK 2BRL 2I1R 2JC0 2JC1
• 分子名称: RNA-DIRECTED RNA POLYMERASE, MANGANESE (II) ION, 6-CYCLOHEXYL-4-METHYL-5-PHENYL-4H-THIENO[3,2-B]PYRROLE-2-CARBOXYLIC ACID, ... (4 entities in total)
• 機能のキーワード: envelope protein, hepatitis c virus, rna-dependent rna-polymerase, nucleotide-binding, allosteric inhibitor, non nucleoside inhibitor, nni, hcv, ns5b, membrane, helicase, hydrolase, polymerase, atp-binding, rna-binding, genotype 1b, viral protein, transmembrane, rna replication
• 由来する生物種: HEPATITIS C VIRUS
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60222.04

構造登録者

Di Marco, S. (登録日: 2009-03-17, 公開日: 2009-08-18, 最終更新日: 2023-12-13)

• 主引用文献: Martin Hernando, J.I.,Ontoria, J.M.,Malancona, S.,Attenni, B.,Fiore, F.,Bonelli, F.,Koch, U.,Di Marco, S.,Colarusso, S.,Ponzi, S.,Gennari, N.,Vignetti, S.E.,Del Rosario Rico Ferreira, M.,Habermann, J.,Rowley, M.,Narjes, F.; Optimization of Thienopyrrole-Based Finger-Loop Inhibitors of the Hepatitis C Virus Ns5B Polymerase.; Chemmedchem, 4:1695-, 2009; PubMed: 19672916; DOI: 10.1002/CMDC.200900184

実験手法

X-RAY DIFFRACTION (2 Å)