2WCX

Crystal Structure of Hepatitis C Virus NS5B Polymerase in Complex with Thienopyrrole-Based Finger-Loop Inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 1532

Chain	Residue
A	ASP220
A	THR221
A	ASP318
A	MN1533
A	HOH2504
A	HOH2505

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 1533

Chain	Residue
A	MN1532
A	HOH2507
A	ASP220
A	ASP318
A	ASP319

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE VGC A 1534

Chain	Residue
A	VAL37
A	LEU392
A	ALA393
A	HIS428
A	LEU492
A	VAL494
A	PRO495
A	ARG503
A	HOH2487
A	HOH2497

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	118
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10557268","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11884572","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"UniProtKB","id":"P26662","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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