2W09

CYP51 OF M. TUBERCULOSIS BOUND TO AN INHIBITOR CIS-4-METHYL-N-[(1S)-3-(METHYLSULFANYL)-1-(PYRIDIN-4-YLCARBAMOYL)PROPYL]CYCLOHEXANECARBOXAMIDE

Summary for 2W09

• Entry DOI: 10.2210/pdb2w09/pdb
• Related: 1E9X 1EA1 1H5Z 1U13 1X8V 2BZ9 2CI0 2CIB 2VKU 2W0A 2W0B
• Descriptor: CYTOCHROME P450 51, PROTOPORPHYRIN IX CONTAINING FE, CIS-4-METHYL-N-[(1S)-3-(METHYLSULFANYL)-1-(PYRIDIN-4-YLCARBAMOYL)PROPYL]CYCLOHEXANECARBOXAMIDE, ... (4 entities in total)
• Functional Keywords: steroid biosynthesis, protein-inhibitor complex, metal-binding, oxidoreductase, lipid synthesis, nadp, iron, heme, cytoplasm, monooxygenase, sterol biosynthesis
• Biological source: MYCOBACTERIUM TUBERCULOSIS
• Total number of polymer chains: 1
• Total formula weight: 52443.26

Authors

Podust, L.M. (deposition date: 2008-08-12, release date: 2009-01-20, Last modification date: 2023-12-13)

• Primary citation: Chen, C.-K.,Doyle, P.S.,Yermalitskaya, L.V.,Mackey, Z.B.,Ang, K.K.H.,Mckerrow, J.H.,Podust, L.M.; Trypanosoma Cruzi Cyp51 Inhibitor Derived from a Mycobacterium Tuberculosis Screen Hit.; Plos Negl Trop Dis, 3:E372-, 2009; PubMed: 19190730; DOI: 10.1371/JOURNAL.PNTD.0000372

Experimental method

X-RAY DIFFRACTION (1.57 Å)