2VKU

4,4'-Dihydroxybenzophenone Mimics Sterol Substrate in the Binding Site of Sterol 14alpha-Demethylase (CYP51) in the X-ray Structure of the Complex

Summary for 2VKU

Entry DOI	10.2210/pdb2vku/pdb
Related	1E9X 1EA1 1H5Z 1U13 1X8V 2BZ9 2CI0 2CIB
Descriptor	CYTOCHROME P450 51, bis(4-hydroxyphenyl)methanone, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
Functional Keywords	steroid biosynthesis, cyp51-4, cytoplasm, alpha-beta, heme co-factor, lipid synthesis, sterol biosynthesis, 4'-dihydroxybenzophenone complex, nadp, iron, heme, monooxygenase, metal-binding, oxidoreductase
Biological source	MYCOBACTERIUM TUBERCULOSIS
Total number of polymer chains	1
Total formula weight	53527.02
Authors	Eddine, A.N.,von Kries, J.P.,Podust, M.V.,Podust, L.M. (deposition date: 2007-12-29, release date: 2008-03-25, Last modification date: 2023-12-13)
Primary citation	Eddine, A.N.,P Von Kries, J.,Podust, M.V.,Warrier, T.,Kaufmann, S.H.E.,Podust, L.M. X-Ray Structure of 4,4'-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14Alpha-Demethylase (Cyp51) J.Biol.Chem., 283:15152-, 2008 Cited by PubMed: 18367444 DOI: 10.1074/JBC.M801145200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation