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2W0A

CYP51 of M. tuberculosis bound to an inhibitor N-[(1S)-2-METHYL-1-(PYRIDIN-4-YLCARBAMOYL)PROPYL]CYCLOHEXANECARBOXAMIDE

Summary for 2W0A
Entry DOI10.2210/pdb2w0a/pdb
Related1E9X 1EA1 1H5Z 1U13 1X8V 2BZ9 2CI0 2CIB 2VKU 2W09 2W0B
DescriptorCYTOCHROME P450 51, PROTOPORPHYRIN IX CONTAINING FE, N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide, ... (4 entities in total)
Functional Keywordssteroid biosynthesis, protein-inhibitor complex, metal-binding, oxidoreductase, lipid synthesis, nadp, iron, heme, cytoplasm, monooxygenase, sterol biosynthesis
Biological sourceMYCOBACTERIUM TUBERCULOSIS
Total number of polymer chains1
Total formula weight52411.20
Authors
Podust, L.M. (deposition date: 2008-08-12, release date: 2009-01-20, Last modification date: 2023-12-13)
Primary citationChen, C.-K.,Doyle, P.S.,Yermalitskaya, L.V.,Mackey, Z.B.,Ang, K.K.H.,Mckerrow, J.H.,Podust, L.M.
Trypanosoma Cruzi Cyp51 Inhibitor Derived from a Mycobacterium Tuberculosis Screen Hit.
Plos Negl Trop Dis, 3:E372-, 2009
Cited by
PubMed: 19190730
DOI: 10.1371/JOURNAL.PNTD.0000372
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

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