2VRW

Critical structural role for the PH and C1 domains of the Vav1 exchange factor

Summary for 2VRW

• Entry DOI: 10.2210/pdb2vrw/pdb
• Related: 1E96 1F5X 1FOE 1G4U 1GCP 1GCQ 1HE1 1HH4 1I4D 1I4L 1I4T 1K1Z 1MH1 1RYF 1RYH 2FJU
• Descriptor: RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, PROTO-ONCOGENE VAV, ZINC ION, ... (4 entities in total)
• Functional Keywords: lipoprotein, gtp-binding, metal-binding, proto-oncogene, phosphoprotein, exchange factor, rac, vav, gtpase, membrane, sh2 domain, sh3 domain, methylation, zinc-finger, prenylation, guanine-nucleotide releasing factor, phorbol-ester binding, adp-ribosylation, nucleotide-binding, signaling protein
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P63000
• Total number of polymer chains: 2
• Total formula weight: 68092.80

Authors

Rapley, J.,Tybulewicz, V.,Rittinger, K. (deposition date: 2008-04-16, release date: 2008-06-17, Last modification date: 2011-07-13)

• Primary citation: Rapley, J.,Tybulewicz, V.,Rittinger, K.; Crucial Structural Role for the Ph and C1 Domains of the Vav1 Exchange Factor.; Embo Rep., 9:655-, 2008; PubMed: 18511940; DOI: 10.1038/EMBOR.2008.80

Experimental method

X-RAY DIFFRACTION (1.85 Å)