2VQW
Structure of inhibitor-free HDAC4 catalytic domain (with gain-of- function mutation His332Tyr)
Summary for 2VQW
Entry DOI | 10.2210/pdb2vqw/pdb |
Related | 2VQJ 2VQM 2VQO 2VQQ 2VQV |
Descriptor | HISTONE DEACETYLASE 4, POTASSIUM ION, ZINC ION (3 entities in total) |
Functional Keywords | inhibitor, repressor, chromatin, coiled coil, histone deacetylase, transcription regulation, ubl conjugation, chromatin regulator, polymorphism, transcription, phosphoprotein, hdac, zinc, hdaci, nucleus, hydrolase, cytoplasm |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: P56524 |
Total number of polymer chains | 1 |
Total formula weight | 44711.44 |
Authors | Bottomley, M.J.,Lo Surdo, P.,Di Giovine, P.,Cirillo, A.,Scarpelli, R.,Ferrigno, F.,Jones, P.,Neddermann, P.,De Francesco, R.,Steinkuhler, C.,Gallinari, P.,Carfi, A. (deposition date: 2008-03-19, release date: 2008-08-05, Last modification date: 2023-12-13) |
Primary citation | Bottomley, M.J.,Lo Surdo, P.,Di Giovine, P.,Cirillo, A.,Scarpelli, R.,Ferrigno, F.,Jones, P.,Neddermann, P.,De Francesco, R.,Steinkuhler, C.,Gallinari, P.,Carfi, A. Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Structural Zinc-Binding Domain. J.Biol.Chem., 283:26694-, 2008 Cited by PubMed: 18614528DOI: 10.1074/JBC.M803514200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
Download full validation report