2VQW

Structure of inhibitor-free HDAC4 catalytic domain (with gain-of- function mutation His332Tyr)

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0000118	cellular_component	histone deacetylase complex
G	0004407	molecular_function	histone deacetylase activity
G	0006325	biological_process	chromatin organization
G	0016575	biological_process	histone deacetylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K G1407

Chain	Residue
G	ASP194
G	ASP196
G	HIS198
G	SER217
G	LEU218

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K G1408

Chain	Residue
G	PHE207
G	ASP210
G	VAL213
G	PHE244

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN G1409

Chain	Residue
G	ASP196
G	HIS198
G	ASP290

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G1410

Chain	Residue
G	CYS23
G	CYS25
G	HIS31
G	CYS107

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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