2VQW

Structure of inhibitor-free HDAC4 catalytic domain (with gain-of- function mutation His332Tyr)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (G)	HISTONE DEACETYLASE 4	polymer	413	44502.4	1	UniProt (P56524) Pfam (PF00850)	HOMO SAPIENS (HUMAN)	HD4
2	B, C (G)	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
3	D, E (G)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

G: 1 - 3 (PDB: 2VQW)
G: 4 - 413 (UniProt: P56524)

PDB	External Database	Details
Tyr 332	His 976	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	44502.4
Non-Polymers*	Number of molecules	4
	Total formula weight	209.0
All*	Total formula weight	44711.4

*Water molecules are not included.