2VQV

Structure of HDAC4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid inhibitor

Summary for 2VQV

Related2VQQ 2VQO 2VQM 2VQJ 2VQW
DescriptorHISTONE DEACETYLASE 4, SULFATE ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywordsinhibitor, repressor, chromatin, coiled coil, histone deacetylase, transcription regulation, ubl conjugation, chromatin regulator, polymorphism, transcription, phosphoprotein, hdac, zinc, hdaci, nucleus, hydrolase, cytoplasm
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus P56524
Total number of polymer chains2
Total molecular weight90284.88
Authors
Bottomley, M.J.,Lo Surdo, P.,Di Giovine, P.,Cirillo, A.,Scarpelli, R.,Ferrigno, F.,Jones, P.,Neddermann, P.,De Francesco, R.,Steinkuhler, C.,Gallinari, P.,Carfi, A. (deposition date: 2008-03-19, release date: 2008-07-22, Last modification date: 2011-07-13)
Primary citation
Bottomley, M.J.,Lo Surdo, P.,Di Giovine, P.,Cirillo, A.,Scarpelli, R.,Ferrigno, F.,Jones, P.,Neddermann, P.,De Francesco, R.,Steinkuhler, C.,Gallinari, P.,Carfi, A.
Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Structural Zinc-Binding Domain.
J.Biol.Chem., 283:26694-, 2008
PubMed: 18614528 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M803514200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2696 0.1% 5.1% 0.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171588
PDB entries from 2020-11-25