2VQW

Structure of inhibitor-free HDAC4 catalytic domain (with gain-of- function mutation His332Tyr)

2VQW の概要

• エントリーDOI: 10.2210/pdb2vqw/pdb
• 関連するPDBエントリー: 2VQJ 2VQM 2VQO 2VQQ 2VQV
• 分子名称: HISTONE DEACETYLASE 4, POTASSIUM ION, ZINC ION (3 entities in total)
• 機能のキーワード: inhibitor, repressor, chromatin, coiled coil, histone deacetylase, transcription regulation, ubl conjugation, chromatin regulator, polymorphism, transcription, phosphoprotein, hdac, zinc, hdaci, nucleus, hydrolase, cytoplasm
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus: P56524
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44711.44

構造登録者

Bottomley, M.J.,Lo Surdo, P.,Di Giovine, P.,Cirillo, A.,Scarpelli, R.,Ferrigno, F.,Jones, P.,Neddermann, P.,De Francesco, R.,Steinkuhler, C.,Gallinari, P.,Carfi, A. (登録日: 2008-03-19, 公開日: 2008-08-05, 最終更新日: 2023-12-13)

• 主引用文献: Bottomley, M.J.,Lo Surdo, P.,Di Giovine, P.,Cirillo, A.,Scarpelli, R.,Ferrigno, F.,Jones, P.,Neddermann, P.,De Francesco, R.,Steinkuhler, C.,Gallinari, P.,Carfi, A.; Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Structural Zinc-Binding Domain.; J.Biol.Chem., 283:26694-, 2008; PubMed: 18614528; DOI: 10.1074/JBC.M803514200

実験手法

X-RAY DIFFRACTION (3 Å)