2VN0

CYP2C8DH COMPLEXED WITH TROGLITAZONE

2VN0 の概要

• エントリーDOI: 10.2210/pdb2vn0/pdb
• 関連するPDBエントリー: 1PQ2 2NNH 2NNI 2NNJ
• 分子名称: CYTOCHROME P450 2C8, PROTOPORPHYRIN IX CONTAINING FE, (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, electron transport, endoplasmic reticulum, metal-binding, palmitic acid, human p450 2c8, troglitazone, polymorphism, monooxygenase, iron, heme, cyp2c8, membrane, microsome, monooxygenases, inhibitor complex
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55368.61

構造登録者

Schoch, G.A.,Yano, J.K.,Sansen, S.,Stout, C.D.,Johnson, E.F. (登録日: 2008-01-30, 公開日: 2008-04-29, 最終更新日: 2023-12-13)

• 主引用文献: Schoch, G.A.,Yano, J.K.,Sansen, S.,Dansette, P.M.,Stout, C.D.,Johnson, E.F.; Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.; J. Biol. Chem., 283:17227-17237, 2008; PubMed: 18413310; DOI: 10.1074/jbc.M802180200

実験手法

X-RAY DIFFRACTION (2.7 Å)