2VN0

CYP2C8DH COMPLEXED WITH TROGLITAZONE

Summary for 2VN0

Entry DOI	10.2210/pdb2vn0/pdb
Related	1PQ2 2NNH 2NNI 2NNJ
Descriptor	CYTOCHROME P450 2C8, PROTOPORPHYRIN IX CONTAINING FE, (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE, ... (5 entities in total)
Functional Keywords	oxidoreductase, electron transport, endoplasmic reticulum, metal-binding, palmitic acid, human p450 2c8, troglitazone, polymorphism, monooxygenase, iron, heme, cyp2c8, membrane, microsome, monooxygenases, inhibitor complex
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	55368.61
Authors	Schoch, G.A.,Yano, J.K.,Sansen, S.,Stout, C.D.,Johnson, E.F. (deposition date: 2008-01-30, release date: 2008-04-29, Last modification date: 2023-12-13)
Primary citation	Schoch, G.A.,Yano, J.K.,Sansen, S.,Dansette, P.M.,Stout, C.D.,Johnson, E.F. Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. J. Biol. Chem., 283:17227-17237, 2008 Cited by PubMed: 18413310 DOI: 10.1074/jbc.M802180200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation