2VN0

CYP2C8DH COMPLEXED WITH TROGLITAZONE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002933	biological_process	lipid hydroxylation
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006082	biological_process	organic acid metabolic process
A	0006629	biological_process	lipid metabolic process
A	0006721	biological_process	terpenoid metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0008202	biological_process	steroid metabolic process
A	0008210	biological_process	estrogen metabolic process
A	0008392	molecular_function	arachidonate epoxygenase activity
A	0008401	molecular_function	retinoic acid 4-hydroxylase activity
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A	0019369	biological_process	arachidonate metabolic process
A	0019373	biological_process	epoxygenase P450 pathway
A	0020037	molecular_function	heme binding
A	0032787	biological_process	monocarboxylic acid metabolic process
A	0034875	molecular_function	caffeine oxidase activity
A	0042178	biological_process	xenobiotic catabolic process
A	0042572	biological_process	retinol metabolic process
A	0042573	biological_process	retinoic acid metabolic process
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0046456	biological_process	icosanoid biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0070989	biological_process	oxidative demethylation
A	0097267	biological_process	omega-hydroxylase P450 pathway
A	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM A 500

Chain	Residue
A	ARG97
A	LEU361
A	VAL366
A	HIS368
A	PRO427
A	PHE428
A	SER429
A	ARG433
A	CYS435
A	ALA436
A	GLU444
A	ILE112
A	TRP120
A	ARG124
A	ALA297
A	GLY298
A	THR301
A	THR302
A	THR305

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TDZ A 501

Chain	Residue
A	ILE106
A	PHE201
A	ASN204
A	PHE205
A	LEU208
A	ARG241
A	VAL296
A	GLU300

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PLM A 502

Chain	Residue
A	ARG105
A	ILE106
A	PHE226
A	PRO227
A	GLY228
A	THR229
A	LEU234

---

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSaGKRICAG

Chain	Residue	Details
A	PHE428-GLY437

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1akd

Chain	Residue	Details
A	GLU300
A	THR301

---