2VIJ
Human BACE-1 in complex with 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin- 2-yl)-5-(ethylamino)-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(1,2,3,4- tetrahydro-1-naphthalenylamino)propyl)benzamide
2VIJ の概要
エントリーDOI | 10.2210/pdb2vij/pdb |
関連するPDBエントリー | 1FKN 1M4H 1PY1 1SGZ 1TQF 1UJJ 1UJK 1W50 1W51 1XN2 1XN3 1XS7 1YM2 1YM4 2B8L 2B8V 2VA5 2VA6 2VA7 2VIE |
分子名称 | BETA-SECRETASE 1, N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylamino]propyl}-3-(1,1-dioxido-1,2-thiazinan-2-yl)-5-(ethylamino)benzamide (3 entities in total) |
機能のキーワード | alternative splicing, beta-site app cleaving enzyme, beta-secretase, aspartyl protease, asp-2, bace-1, zymogen, protease, membrane, hydrolase, memapsin-2, glycoprotein, transmembrane |
由来する生物種 | HOMO SAPIENS (HUMAN) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 44942.86 |
構造登録者 | Beswick, P.,Charrier, N.,Clarke, B.,Demont, E.,Dingwall, C.,Dunsdon, R.,Faller, A.,Gleave, R.,Hawkins, J.,Hussain, I.,Johnson, C.N.,Macpherson, D.,Maile, G.,Matico, R.,Milner, P.,Mosley, J.,Naylor, A.,O'Brien, A.,Redshaw, S.,Riddell, D.,Rowland, P.,Skidmore, J.,Soleil, V.,Smith, K.J.,Stanway, S.,Stemp, G.,Stuart, A.,Sweitzer, S.,Theobald, P.,Vesey, D.,Walter, D.S.,Ward, J.,Wayne, G. (登録日: 2007-12-04, 公開日: 2008-01-29, 最終更新日: 2019-09-18) |
主引用文献 | Beswick, P.,Charrier, N.,Clarke, B.,Demont, E.,Dingwall, C.,Dunsdon, R.,Faller, A.,Gleave, R.,Hawkins, J.,Hussain, I.,Johnson, C.N.,Macpherson, D.,Maile, G.,Matico, R.,Milner, P.,Mosley, J.,Naylor, A.,O'Brien, A.,Redshaw, S.,Riddell, D.,Rowland, P.,Skidmore, J.,Soleil, V.,Smith, K.J.,Stanway, S.,Stemp, G.,Stuart, A.,Sweitzer, S.,Theobald, P.,Vesey, D.,Walter, D.S.,Ward, J.,Wayne, G. Bace-1 Inhibitors Part 3: Identification of Hydroxy Ethylamines (Heas) with Nanomolar Potency in Cells. Bioorg.Med.Chem.Lett., 18:1022-, 2008 Cited by PubMed: 18171615DOI: 10.1016/J.BMCL.2007.12.020 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.6 Å) |
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