2VE1
Isopenicillin N synthase with substrate analogue AsMCOV (oxygen exposed 1min 20bar)
Summary for 2VE1
Entry DOI | 10.2210/pdb2ve1/pdb |
Related | 1BK0 1BLZ 1HB1 1HB2 1HB3 1HB4 1IPS 1OBN 1OC1 1ODM 1ODN 1QIQ 1QJE 1QJF 1UZW 1W03 1W04 1W05 1W06 1W3V 1W3X 2BJS 2BU9 2IVI 2IVJ 2JB4 2VAU 2VBB 2VBD 2VBP 2VCM |
Descriptor | ISOPENICILLIN N SYNTHETASE, FE (II) ION, N~6~-[(1R)-1-({[(1R,2R)-1-CARBOXY-3-HYDROXY-2-METHYLPROPYL]OXY}CARBONYL)-2-MERCAPTOPROP-2-EN-1-YL]-6-OXO-L-LYSINE, ... (5 entities in total) |
Functional Keywords | antibiotic biosynthesis, penicillin biosynthesis, iron, oxygenase, vitamin c, metal-binding, monocyclic intermediate, oxidoreductase, b-lactam antibiotic |
Biological source | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
Total number of polymer chains | 1 |
Total formula weight | 38390.55 |
Authors | Ge, W.,Clifton, I.J.,Adlington, R.M.,Baldwin, J.E.,Rutledge, P.J. (deposition date: 2007-10-15, release date: 2008-11-04, Last modification date: 2024-05-08) |
Primary citation | Ge, W.,Clifton, I.J.,Howard-Jones, A.R.,Stok, J.E.,Adlington, R.M.,Baldwin, J.E.,Rutledge, P.J. Structural Studies on the Reaction of Isopenicillin N Synthase with a Sterically Demanding Depsipeptide Substrate Analogue. Chembiochem, 10:2025-, 2009 Cited by PubMed: 19598184DOI: 10.1002/CBIC.200900080 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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