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2VD6

Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate.

Summary for 2VD6
Entry DOI10.2210/pdb2vd6/pdb
Related2J91
DescriptorADENYLOSUCCINATE LYASE, ADENOSINE MONOPHOSPHATE, FUMARIC ACID, ... (7 entities in total)
Functional Keywordspurine biosynthesis, lyase, epilepsy, purine metabolism
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains4
Total formula weight231327.86
Authors
Primary citationStenmark, P.,Moche, M.,Arrowsmith, C.,Berglund, H.,Busam, R.,Collins, R.,Dahlgren, L.G.,Edwards, A.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Hallberg, B.M.,Holmberg-Schiavone, L.,Johansson, I.,Kallas, A.,Karlberg, T.,Kotenyova, T.,Lehtio, L.,Nilsson, M.,Nyman, T.,Ogg, D.,Persson, C.,Sagemark, J.,Sundstrom, M.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Weigelt, J.,Welin, M.,Nordlund, P.
Human Adenylosuccinate Lyase in Complex with its Substrate N6-(1,2-Dicarboxyethyl)-AMP, and its Products AMP and Fumarate.
To be Published,
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

數據於2024-03-27公開中

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