2VCM

Isopenicillin N synthase with substrate analogue AsMCOV

Summary for 2VCM

• Entry DOI: 10.2210/pdb2vcm/pdb
• Related: 1BK0 1BLZ 1HB1 1HB2 1HB3 1HB4 1IPS 1OBN 1OC1 1ODM 1ODN 1QIQ 1QJE 1QJF 1UZW 1W03 1W04 1W05 1W06 1W3V 1W3X 2BJS 2BU9 2IVI 2IVJ 2JB4 2VAU 2VBB 2VBD 2VBP
• Descriptor: ISOPENICILLIN N SYNTHETASE, FE (II) ION, N^6^-[(1R,2S)-1-({[(1R)-1-carboxy-2-methylpropyl]oxy}carbonyl)-2-sulfanylpropyl]-6-oxo-L-lysine, ... (5 entities in total)
• Functional Keywords: antibiotic biosynthesis, penicillin biosynthesis, iron, oxygenase, vitamin c, metal-binding, monocyclic intermediate, oxidoreductase, b-lactam antibiotic
• Biological source: EMERICELLA NIDULANS
• Total number of polymer chains: 1
• Total formula weight: 38190.25

Authors

Ge, W.,Clifton, I.J.,Adlington, R.M.,Baldwin, J.E.,Rutledge, P.J. (deposition date: 2007-09-25, release date: 2008-11-04, Last modification date: 2023-12-13)

• Primary citation: Ge, W.,Clifton, I.J.,Howard-Jones, A.R.,Stok, J.E.,Adlington, R.M.,Baldwin, J.E.,Rutledge, P.J.; Structural Studies on the Reaction of Isopenicillin N Synthase with a Sterically Demanding Depsipeptide Substrate Analogue.; Chembiochem, 10:2025-, 2009; PubMed: 19598184; DOI: 10.1002/CBIC.200900080

Experimental method

X-RAY DIFFRACTION (1.65 Å)