2VBD

Isopenicillin N synthase with substrate analogue L,L,L-ACOMP (unexposed)

Summary for 2VBD

• Entry DOI: 10.2210/pdb2vbd/pdb
• Related: 1BK0 1BLZ 1HB1 1HB2 1HB3 1HB4 1IPS 1OBN 1OC1 1ODM 1ODN 1QIQ 1QJE 1QJF 1UZW 1W03 1W04 1W05 1W06 1W3V 1W3X 2BJS 2BU9 2IVI 2IVJ 2JB4 2VAU 2VBB
• Descriptor: ISOPENICILLIN N SYNTHETASE, FE (II) ION, N^6^-[(1R)-2-[(1R)-1-carboxy-2-(methylsulfanyl)ethoxy]-2-oxo-1-(sulfanylmethyl)ethyl]-6-oxo-L-lysine, ... (4 entities in total)
• Functional Keywords: antibiotic biosynthesis, penicillin biosynthesis, iron, oxygenase, vitamin c, metal-binding, monocyclic intermediate, oxidoreductase, b-lactam antibiotic
• Biological source: EMERICELLA NIDULANS (ASPERGILLUS NIDULANS)
• Total number of polymer chains: 1
• Total formula weight: 38002.13

Authors

Ge, W.,Clifton, I.J.,Adlington, R.M.,Baldwin, J.E.,Rutledge, P.J. (deposition date: 2007-09-10, release date: 2008-09-23, Last modification date: 2023-12-13)

• Primary citation: Ge, W.,Clifton, I.J.,Stok, J.E.,Adlington, R.M.,Baldwin, J.E.,Rutledge, P.J.; The Crystal Structure of an Lll-Configured Depsipeptide Substrate Analogue Bound to Isopenicillin N Synthase.; Org.Biomol.Chem., 8:122-, 2010; PubMed: 20024142; DOI: 10.1039/B910170E

Experimental method

X-RAY DIFFRACTION (2 Å)