2V1Y

Structure of a phosphoinositide 3-kinase alpha adaptor-binding domain (ABD) in a complex with the iSH2 domain from p85 alpha

2V1Y の概要

• エントリーDOI: 10.2210/pdb2v1y/pdb
• 関連するPDBエントリー: 1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI
• 分子名称: PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA (3 entities in total)
• 機能のキーワード: kinase, cancer, sh2 domain, sh3 domain, transferase, oncogenic mutations, host-virus interaction, phosphorylation, disease mutation, phosphoinositide, phospholipid, phospholipid signalling, phosphoinositide 3-kinase, signal transduction
• 由来する生物種: BOS TAURUS (BOVINE); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34044.88

構造登録者

Miled, N.,Yan, Y.,Hon, W.C.,Perisic, O.,Zvelebil, M.,Inbar, Y.,Schneidman-Duhovny, D.,Wolfson, H.J.,Backer, J.M.,Williams, R.L. (登録日: 2007-05-30, 公開日: 2007-07-24, 最終更新日: 2011-07-13)

• 主引用文献: Miled, N.,Yan, Y.,Hon, W.C.,Perisic, O.,Zvelebil, M.,Inbar, Y.,Schneidman-Duhovny, D.,Wolfson, H.J.,Backer, J.M.,Williams, R.L.; Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit.; Science, 317:239-, 2007; PubMed: 17626883; DOI: 10.1126/SCIENCE.1135394

実験手法

X-RAY DIFFRACTION (2.4 Å)