2V1Y
Structure of a phosphoinositide 3-kinase alpha adaptor-binding domain (ABD) in a complex with the iSH2 domain from p85 alpha
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM | polymer | 108 | 12821.5 | 1 | UniProt (P32871) Pfam (PF02192) | BOS TAURUS (BOVINE) | PHOSPHOINOSITIDE 3-KINASE P110 ALPHA, PI3-KINASE P110 SUBUNIT ALPHA, PTDINS-3-KINASE P110, PI3K |
| 2 | B (B) | PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA | polymer | 170 | 21223.4 | 1 | UniProt (P27986) Pfam (PF16454) | HOMO SAPIENS (HUMAN) | PHOSPHOINOSITIDE 3-KINASE P85 ALPHA, PI3-KINASE P85-SUBUNIT ALPHA, PTDINS-3-KINASE P85-ALPHA, PI3K |
| 3 | C, D (A, B) | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
B: 431 - 600 (UniProt: P27986)
| PDB | External Database | Details |
|---|---|---|
| Lys 451 | Glu 451 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34044.9 | |
| All* | Total formula weight | 34044.9 |
