2UXN

Structural Basis of Histone Demethylation by LSD1 Revealed by Suicide Inactivation

2UXN の概要

• エントリーDOI: 10.2210/pdb2uxn/pdb
• 関連するPDBエントリー: 2B2T 2B2U 2B2V 2B2W 2C1J 2C1N 2COM 2CV5 2H94 2IW5 2UXX
• 分子名称: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, HISTONE H3.1, ... (7 entities in total)
• 機能のキーワード: oxidoreductase-transcription regulator complex, oxidoreductase-repressor complex, histone demethylase, fad, lsd1, corest, repressor, transcription regulation, host-virus interaction, chromatin demethylation, nuclear protein, phosphorylation, chromatin regulator, nucleosomes, transcription, oxidoreductase, oxidoreductase/transcription regulator
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Nucleus: O60341 Q9UKL0 P68431
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 103819.83

構造登録者

Yang, M.,Culhane, J.C.,Szewczuk, L.M.,Gocke, C.B.,Brautigam, C.A.,Tomchick, D.R.,Machius, M.,Cole, P.A.,Yu, H. (登録日: 2007-03-28, 公開日: 2007-05-29, 最終更新日: 2011-07-13)

• 主引用文献: Yang, M.,Culhane, J.C.,Szewczuk, L.M.,Gocke, C.B.,Brautigam, C.A.,Tomchick, D.R.,Machius, M.,Cole, P.A.,Yu, H.; Structural Basis of Histone Demethylation by Lsd1 Revealed by Suicide Inactivation.; Nat.Struct.Mol.Biol., 14:535-, 2007; PubMed: 17529991; DOI: 10.1038/NSMB1255

実験手法

X-RAY DIFFRACTION (2.72 Å)