2UVV

Crystal structures of mutant Dpo4 DNA polymerases with 8-oxoG containing DNA template-primer constructs

2UVV の概要

• エントリーDOI: 10.2210/pdb2uvv/pdb
• 関連するPDBエントリー: 1JX4 1JXL 1N48 1N56 1RYR 1RYS 1S0M 1S0N 1S0O 1S10 1S97 1S9F 2AGO 2AGP 2AGQ 2ASD 2ASJ 2ASL 2ATL 2AU0 2BQ3 2BQR 2BQU 2BR0 2C22 2C28 2C2D 2C2E 2C2R 2J6S 2J6T 2J6U 2JEF 2JEG 2JEI 2JEJ 2UVR 2UVU 2UVW
• 分子名称: DNA POLYMERASE IV, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*CP*C)-3', 5'-D(*TP*CP*AP*CP*8OGP*GP*AP*AP*TP*CP *CP*TP*TP*CP*CP*CP*CP*C)-3', ... (6 entities in total)
• 機能のキーワード: transferase, dna-directed dna polymerase, p2 dna polymerase iv, nucleotidyltransferase, 7, magnesium, dna damage, dna repair, dna-binding, translesion dna polymerase, metal-binding, 8-dihydro-8- oxodeoxyguanosine, metal- binding, mutator protein, dna replication
• 由来する生物種: SULFOLOBUS SOLFATARICUS
• 細胞内の位置: Cytoplasm : Q97W02
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 51460.42

構造登録者

Irimia, A.,Egli, M. (登録日: 2007-03-14, 公開日: 2007-05-08, 最終更新日: 2023-12-13)

• 主引用文献: Eoff, R.L.,Irimia, A.,Angel, K.C.,Egli, M.,Guengerich, F.P.; Hydrogen Bonding of 7,8-Dihydro-8-Oxodeoxyguanosine with a Charged Residue in the Little Finger Domain Determines Miscoding Events in Sulfolobus Solfataricus DNA Polymerase Dpo4.; J.Biol.Chem., 282:19831-, 2007; PubMed: 17468100; DOI: 10.1074/JBC.M702290200

実験手法

X-RAY DIFFRACTION (2.2 Å)