2QTC

E. coli Pyruvate dehydrogenase E1 component E401K mutant with phosphonolactylthiamin diphosphate

2QTC の概要

• エントリーDOI: 10.2210/pdb2qtc/pdb
• 関連するPDBエントリー: 2G25 2G28 2IEA 2QTA
• 分子名称: Pyruvate dehydrogenase E1 component, MAGNESIUM ION, 3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-{(1S)-1-HYDROXY-1-[(R)-HYDROXY(METHOXY)PHOSPHORYL]ETHYL}-5-(2-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM, ... (4 entities in total)
• 機能のキーワード: pyruvate dehydrogenase, thiamin diphosphate, glycolysis, magnesium, metal-binding, oxidoreductase, thiamine pyrophosphate
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 200489.82

構造登録者

Furey, W.,Arjunan, P.,Chandrasekhar, K. (登録日: 2007-08-01, 公開日: 2007-08-14, 最終更新日: 2023-08-30)

• 主引用文献: Kale, S.,Arjunan, P.,Furey, W.,Jordan, F.; A Dynamic Loop at the Active Center of the Escherichia coli Pyruvate Dehydrogenase Complex E1 Component Modulates Substrate Utilization and Chemical Communication with the E2 Component; J.Biol.Chem., 282:28106-28116, 2007; PubMed: 17635929; DOI: 10.1074/jbc.M704326200

実験手法

X-RAY DIFFRACTION (1.77 Å)