2QRV

Structure of Dnmt3a-Dnmt3L C-terminal domain complex

2QRV の概要

• エントリーDOI: 10.2210/pdb2qrv/pdb
• 関連するPDBエントリー: 2PV0 2PVC
• 分子名称: DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3-like, S-ADENOSYL-L-HOMOCYSTEINE (3 entities in total)
• 機能のキーワード: dna methyltransferase 3a (dnmt3a) and its regulatory factor, dna methyltransferase 3-like protein (dnmt3l), nucleus, s-adenosyl-l-methionine, transferase-transferase regulator complex, transferase/transferase regulator
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: Q9Y6K1; Nucleus (Probable): Q9UJW3
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 244152.18

構造登録者

Jia, D.,Cheng, X. (登録日: 2007-07-29, 公開日: 2007-12-04, 最終更新日: 2023-08-30)

• 主引用文献: Jia, D.,Jurkowska, R.Z.,Zhang, X.,Jeltsch, A.,Cheng, X.; Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation.; Nature, 449:248-251, 2007; PubMed: 17713477; DOI: 10.1038/nature06146

実験手法

X-RAY DIFFRACTION (2.89 Å)