Crystal Structure of PPARgamma ligand binding domain bound to partial agonist SR145

Summary for 2Q61

Related2Q59 2Q5P 2Q5S 2Q6R 2Q6S
DescriptorPeroxisome Proliferator-Activated Receptor gamma, 1-BENZYL-5-CHLORO-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID (3 entities in total)
Functional Keywordsprotein-ligand complex, ligand binding protein
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight63378.4
Bruning, J.B.,Nettles, K.W. (deposition date: 2007-06-04, release date: 2007-10-23, Last modification date: 2017-10-18)
Primary citation
Bruning, J.B.,Chalmers, M.J.,Prasad, S.,Busby, S.A.,Kamenecka, T.M.,He, Y.,Nettles, K.W.,Griffin, P.R.
Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism
Structure, 15:1258-1271, 2007
PubMed: 17937915 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2007.07.014
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22390.2%6.1%10.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report