Crystal Structure of PPARgamma bound to partial agonist MRL24

Summary for 2Q5P

Related2Q59 2Q5S 2Q61 2Q6R 2Q6S
DescriptorPeroxisome Proliferator-Activated Receptor gamma, (2S)-2-(3-{[1-(4-METHOXYBENZOYL)-2-METHYL-5-(TRIFLUOROMETHOXY)-1H-INDOL-3-YL]METHYL}PHENOXY)PROPANOIC ACID (3 entities in total)
Functional Keywordsprotein-ligand complex, ligand binding protein
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight63645.6
Bruning, J.B.,Nettles, K.W. (deposition date: 2007-06-01, release date: 2007-10-23, Last modification date: 2017-10-18)
Primary citation
Bruning, J.B.,Chalmers, M.J.,Prasad, S.,Busby, S.A.,Kamenecka, T.M.,He, Y.,Nettles, K.W.,Griffin, P.R.
Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism
Structure, 15:1258-1271, 2007
PubMed: 17937915 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2007.07.014
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.28880.4%5.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report