2PWC

HIV-1 protease in complex with a amino decorated pyrrolidine-based inhibitor

2PWC の概要

• エントリーDOI: 10.2210/pdb2pwc/pdb
• 関連するPDBエントリー: 1XL2 2PQZ 2PWR
• 分子名称: Gag-Pol polyprotein (Pr160Gag-Pol), CHLORIDE ION, N,N'-(3S,4S)-PYRROLIDINE-3,4-DIYLBIS(4-AMINO-N-BENZYLBENZENESULFONAMIDE), ... (5 entities in total)
• 機能のキーワード: protein-ligand complex, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22397.71

構造登録者

Boettcher, J.,Blum, A.,Heine, A.,Diederich, W.E.,Klebe, G. (登録日: 2007-05-11, 公開日: 2008-04-15, 最終更新日: 2024-03-13)

• 主引用文献: Blum, A.,Bottcher, J.,Heine, A.,Klebe, G.,Diederich, W.E.; Structure-Guided Design of C2-Symmetric HIV-1 Protease Inhibitors Based on a Pyrrolidine Scaffold.; J.Med.Chem., 51:2078-2087, 2008; PubMed: 18348517; DOI: 10.1021/jm701142s

実験手法

X-RAY DIFFRACTION (1.78 Å)