2PKS

Thrombin in complex with inhibitor

Summary for 2PKS

• Entry DOI: 10.2210/pdb2pks/pdb
• Descriptor: Thrombin light chain, Thrombin heavy chain fragment, Hirudin, ... (7 entities in total)
• Functional Keywords: inhibitor complex, thrombin inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734 P00734; Secreted: P28504
• Total number of polymer chains: 4
• Total formula weight: 33554.39

Authors

Xue, Y. (deposition date: 2007-04-18, release date: 2008-04-22, Last modification date: 2017-10-18)

• Primary citation: Blomberg, D.,Fex, T.,Xue, Y.,Brickmann, K.,Kihlberg, J.; Design, synthesis and biological evaluation of thrombin inhibitors based on a pyridine scaffold.; Org.Biomol.Chem., 5:2599-2605, 2007; PubMed: 18019535; DOI: 10.1039/b705344d

Experimental method

X-RAY DIFFRACTION (2.5 Å)