2PDX

Human aldose reductase double mutant S302R-C303D complexed with zopolrestat.

Summary for 2PDX

Entry DOI	10.2210/pdb2pdx/pdb
Related	2HVN 2PD5 2PD9 2PDB 2PDC 2PDF 2PDG 2PDH 2PDI 2PDJ 2PDK 2PDL 2PDM 2PDN 2PDP 2PDQ 2PDU 2PDW 2PDY
Descriptor	Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ... (4 entities in total)
Functional Keywords	tim barrel, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	37143.18
Authors	Steuber, H.,Heine, A.,Klebe, G. (deposition date: 2007-04-01, release date: 2008-04-01, Last modification date: 2023-08-30)
Primary citation	Steuber, H.,Heine, A.,Podjarny, A.,Klebe, G. Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features. J.Mol.Biol., 379:991-1016, 2008 Cited by PubMed: 18495158 DOI: 10.1016/j.jmb.2008.03.063 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation