2PDX
Human aldose reductase double mutant S302R-C303D complexed with zopolrestat.
Summary for 2PDX
Entry DOI | 10.2210/pdb2pdx/pdb |
Related | 2HVN 2PD5 2PD9 2PDB 2PDC 2PDF 2PDG 2PDH 2PDI 2PDJ 2PDK 2PDL 2PDM 2PDN 2PDP 2PDQ 2PDU 2PDW 2PDY |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ... (4 entities in total) |
Functional Keywords | tim barrel, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37143.18 |
Authors | Steuber, H.,Heine, A.,Klebe, G. (deposition date: 2007-04-01, release date: 2008-04-01, Last modification date: 2023-08-30) |
Primary citation | Steuber, H.,Heine, A.,Podjarny, A.,Klebe, G. Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features. J.Mol.Biol., 379:991-1016, 2008 Cited by PubMed: 18495158DOI: 10.1016/j.jmb.2008.03.063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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