2PDL
Human aldose reductase mutant L301M complexed with tolrestat.
Summary for 2PDL
Entry DOI | 10.2210/pdb2pdl/pdb |
Related | 1AH3 2FZB 2FZD 2PD5 2PD9 2PDB 2PDC 2PDF 2PDG 2PDH 2PDI 2PDJ 2PDK 2PDM 2PDN 2PDP 2PDQ 2PDU 2PDW 2PDX 2PDY |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TOLRESTAT, ... (4 entities in total) |
Functional Keywords | tim barrel, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37017.13 |
Authors | Steuber, H.,Heine, A.,Klebe, G. (deposition date: 2007-04-01, release date: 2008-04-01, Last modification date: 2023-08-30) |
Primary citation | Steuber, H.,Heine, A.,Podjarny, A.,Klebe, G. Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features. J.Mol.Biol., 379:991-1016, 2008 Cited by PubMed: 18495158DOI: 10.1016/j.jmb.2008.03.063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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