2OPN

Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-527

Summary for 2OPN

• Entry DOI: 10.2210/pdb2opn/pdb
• Related: 1YV5 2OPM
• Descriptor: Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)], MAGNESIUM ION, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: protein-bisphosphonate complex, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14324
• Total number of polymer chains: 1
• Total formula weight: 43544.80

Authors

Cao, R.,Gao, Y.G.,Robinson, H.,Goddard, A.,Oldfield, E. (deposition date: 2007-01-29, release date: 2007-10-02, Last modification date: 2023-08-30)

• Primary citation: Zhang, Y.,Cao, R.,Leon, A.,Guo, R.T.,Krysiak, K.,Yin, F.,Hudock, M.P.,Mukherjee, S.,Gao, Y.G.,Robinson, H.,Song, Y.,No, J.H.,Hong, W.,Morita, C.,Wang, A.H.-J.,Oldfield, E.; Bisphosphonates: Teaching Old Drugs with New Tricks; To be Published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)