NMR solution structure of HIV-1 nucleocapsid protein in complex with an inhibitor displaying a 2 inhibitors:1 NC stoichiometry

Summary for 2M3Z

Related1A1T 1F6U
DescriptorNUCLEOCAPSID PROTEIN P7, ZINC ION, (3E)-3-{(2Z)-[(5Z)-5-(furan-2-ylmethylidene)-4-oxo-1,3-thiazolidin-2-ylidene]hydrazinylidene}-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3 entities in total)
Functional Keywordshiv-1 nc, viral protein
Biological sourceHuman immunodeficiency virus type 1 (HIV-1)
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential) P12497
Total number of polymer chains1
Total molecular weight7336.08
Goudreau, N.,Hucke, O. (deposition date: 2013-01-28, release date: 2013-02-27, Last modification date: 2013-05-29)
Primary citation
Goudreau, N.,Hucke, O.,Faucher, A.M.,Grand-Maitre, C.,Lepage, O.,Bonneau, P.R.,Mason, S.W.,Titolo, S.
Discovery and Structural Characterization of a New Inhibitor Series of HIV-1 Nucleocapsid Function: NMR Solution Structure Determination of a Ternary Complex Involving a 2:1 Inhibitor/NC Stoichiometry.
J.Mol.Biol., 425:1982-1998, 2013
PubMed: 23485336 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2013.02.022
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers001.3%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures