2M3Z

NMR solution structure of HIV-1 nucleocapsid protein in complex with an inhibitor displaying a 2 inhibitors:1 NC stoichiometry

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 101

Chain	Residue
A	CYS15
A	CYS18
A	HIS23
A	CYS28

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 102

Chain	Residue
A	CYS36
A	CYS39
A	HIS44
A	CYS49

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site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 1HF A 103

Chain	Residue
A	ASN8
A	GLN9
A	VAL13
A	LYS14
A	CYS15
A	PHE16
A	ILE24
A	ALA25
A	LYS26
A	ARG32
A	TRP37
A	MET46
A	1HF104
A	LYS3

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site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 1HF A 104

Chain	Residue
A	ARG32
A	LYS33
A	GLY35
A	CYS36
A	TRP37
A	GLN45
A	MET46
A	LYS47
A	1HF103

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	17
Details	ZN_FING: CCHC-type 1 => ECO:0000255|PROSITE-ProRule:PRU00047

Chain	Residue	Details
A	VAL13-ALA30

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site_id	SWS_FT_FI2
Number of Residues	17
Details	ZN_FING: CCHC-type 2 => ECO:0000255|PROSITE-ProRule:PRU00047

Chain	Residue	Details
A	LYS34-GLU51

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by viral protease => ECO:0000255

Chain	Residue	Details
A	ASN55

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