2KM3

Structure of an intramolecular G-quadruplex containing a G.C.G.C tetrad formed by human telomeric variant CTAGGG repeats

Summary for 2KM3

• Entry DOI: 10.2210/pdb2km3/pdb
• Related: 143D 1K8P 2AQY 2GKU 2JSK 2JSL 2JSM 2JSQ 2KF7 2KF8
• Descriptor: DNA (5'-D(*AP*GP*GP*GP*CP*TP*AP*GP*GP*GP*CP*TP*AP*GP*GP*GP*CP*TP*AP*GP*GP*G)-3') (1 entity in total)
• Functional Keywords: anticancer targets, ctaggg repeat, g-quadruplex, human telomere instability, dna
• Total number of polymer chains: 1
• Total formula weight: 6938.46

Authors

Lim, K.W.,Alberti, P.,Guedin, A.,Lacroix, L.,Riou, J.F.,Royle, N.J.,Mergny, J.L.,Phan, A.T. (deposition date: 2009-07-17, release date: 2009-11-03, Last modification date: 2011-07-13)

• Primary citation: Lim, K.W.,Alberti, P.,Guedin, A.,Lacroix, L.,Riou, J.F.,Royle, N.J.,Mergny, J.L.,Phan, A.T.; Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad; Nucleic Acids Res., 37:6239-6248, 2009; PubMed: 19692585; DOI: 10.1093/nar/gkp630

Experimental method

SOLUTION NMR