2GKU

Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures

Summary for 2GKU

Entry DOI	10.2210/pdb2gku/pdb
Related	143D 186D 1K8P 2AQY
Descriptor	Human telomere DNA (1 entity in total)
Functional Keywords	g-tetrad; 3+1 strand folding;edgewise, double-chain reversal loops; nmr, 12 structures, dna
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	7591.88
Authors	Luu, K.N.,Phan, A.T.,Kuryavyi, V.V.,Lacroix, L.,Patel, D.J. (deposition date: 2006-04-03, release date: 2006-08-15, Last modification date: 2024-05-29)
Primary citation	Luu, K.N.,Phan, A.T.,Kuryavyi, V.V.,Lacroix, L.,Patel, D.J. Structure of the human telomere in k(+) solution: an intramolecular (3 + 1) g-quadruplex scaffold. J.Am.Chem.Soc., 128:9963-9970, 2006 Cited by PubMed Abstract: We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA. PubMed: 16866556 DOI: 10.1021/ja062791w PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation